OVERVIEW
FOXO4-DRI is a research peptide used in preclinical laboratory models involving metabolic, mitochondrial, immune, or regenerative pathways.
What is it?
FOXO4-DRI is a synthetic, cell-penetrating research peptide developed for investigational and in vitro research use, designed to modulate protein-protein interactions involving the transcription factor FOXO4. It has primarily been studied in cellular senescence research as a tool to explore how senescent cells maintain survival signaling under stress.
In preclinical and laboratory models, FOXO4-DRI has been examined for its ability to disrupt FOXO4-associated signaling complexes that are linked to pro-survival pathways in senescent cells, with downstream effects that can influence apoptosis-related signaling under controlled experimental conditions. These characteristics have made it a compound of interest in experimental studies focused on senescence biology, stress-response signaling, and pathways associated with cellular aging mechanisms.
MECHANISM OF INTEREST
|
Pathway |
Description |
|
Angiogenesis |
Observed to influence vascular endothelial pathways. |
|
Tissue Repair |
Supports modeling of gastric, tendon, and muscular healing. |
|
Cytoprotection |
Evaluated for protective effects in oxidative environments. |
KEY RESEARCH APPLICATIONS
- Tissue repair and regeneration research
- Inflammation pathway modeling
- Angiogenesis studies
SPECIFICATIONS
|
Attribute |
Detail |
|
Purity |
≥ 98% (HPLC) |
|
Form |
Lyophilized peptide |
|
Appearance |
White to off-white powder |
|
Molecular Weight |
~1419 Da |
|
Container |
Sterile glass vial |
HANDLING & STORAGE
Lyophilized: Store at –20°C, protect from light and moisture.
Reconstituted: Store at 2–8°C, avoid freeze–thaw cycles.
RESEARCH USE ONLY
This product is supplied strictly for laboratory, research, and development use. Not for human consumption or therapeutic application.